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RECOMB
2009
Springer
14 years 7 months ago
Parameter Synthesis in Nonlinear Dynamical Systems: Application to Systems Biology
The dynamics of biological processes are often modeled as systems of nonlinear ordinary differential equations (ODE). An important feature of nonlinear ODEs is that seemingly minor...
Alexandre Donzé, Gilles Clermont, Axel Lega...
ISMB
2007
13 years 9 months ago
A Chado case study: an ontology-based modular schema for representing genome-associated biological information
Motivation: A few years ago, FlyBase undertook to design a new database schema to store Drosophila data. It would fully integrate genomic sequence and annotation data with bibliog...
Chris Mungall, David B. Emmert
ECCB
2008
IEEE
13 years 6 months ago
Temporal logic patterns for querying dynamic models of cellular interaction networks
Abstract: Models of the dynamics of cellular interaction networks have become increasingly larger in recent years. Formal verification based on model checking provides a powerful t...
Pedro T. Monteiro, Delphine Ropers, Radu Mateescu,...
SIGMETRICS
2008
ACM
130views Hardware» more  SIGMETRICS 2008»
13 years 6 months ago
Using probabilistic model checking in systems biology
Probabilistic model checking is a formal verification framework for systems which exhibit stochastic behaviour. It has been successfully applied to a wide range of domains, includ...
Marta Z. Kwiatkowska, Gethin Norman, David Parker
GECCO
2007
Springer
153views Optimization» more  GECCO 2007»
14 years 26 days ago
Analyzing the effects of module encapsulation on search space bias
Modularity is thought to improve the evolvability of biological systems [18, 22]. Recent studies in the field of evolutionary computation show that the use of modularity improves...
Ozlem O. Garibay, Annie S. Wu