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BMCBI
2008
120views more  BMCBI 2008»
13 years 7 months ago
Statistical issues in the analysis of Illumina data
Background: Illumina bead-based arrays are becoming increasingly popular due to their high degree of replication and reported high data quality. However, little attention has been...
Mark J. Dunning, Nuno L. Barbosa-Morais, Andy G. L...
BMCBI
2008
108views more  BMCBI 2008»
13 years 7 months ago
An analysis of the positional distribution of DNA motifs in promoter regions and its biological relevance
Background: Motif finding algorithms have developed in their ability to use computationally efficient methods to detect patterns in biological sequences. However the posterior cla...
Ana C. Casimiro, Susana Vinga, Ana T. Freitas, Arl...
BMCBI
2008
102views more  BMCBI 2008»
13 years 7 months ago
mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control-region sequences
Background: For the past few years, scientific controversy has surrounded the large number of errors in forensic and literature mitochondrial DNA (mtDNA) data. However, recent res...
Hwan Young Lee, Injee Song, Eunho Ha, Sung-Bae Cho...
BMCBI
2008
96views more  BMCBI 2008»
13 years 7 months ago
Mapping proteins to disease terminologies: from UniProt to MeSH
Background: Although the UniProt KnowledgeBase is not a medical-oriented database, it contains information on more than 2,000 human proteins involved in pathologies. However, thes...
Anaïs Mottaz, Yum Lina Yip, Patrick Ruch, Ann...
BMCBI
2008
102views more  BMCBI 2008»
13 years 7 months ago
Stability of the core domain of p53: insights from computer simulations
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...
Arumugam Madhumalar, Derek John Smith, Chandra Ver...
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