The accurate prediction of enzyme catalytic sites remains an open problem in bioinformatics. Recently, several structure-based methods have become popular; however, few robust seq...
Abstract--Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of ...
The availability of whole genome sequences and high-throughput genomic assays opens the door for in silico analysis of transcription regulation. This includes methods for discover...
Yoseph Barash, Gal Elidan, Nir Friedman, Tommy Kap...
Background: Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target prote...
Khader Shameer, Lalima L. Madan, Shivamurthy Veera...
One of the major limitations of HMM-based models is the inability to cope with topology: When applied to a visible observation (VO) sequence, HMM-based techniques have difficulty ...