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BMCBI
2004
94views more  BMCBI 2004»
13 years 10 months ago
GASP: Gapped Ancestral Sequence Prediction for proteins
Background: The prediction of ancestral protein sequences from multiple sequence alignments is useful for many bioinformatics analyses. Predicting ancestral sequences is not a sim...
Richard J. Edwards, Denis C. Shields
ISMB
1998
13 years 11 months ago
Sequence Assembly Validation by Multiple Restriction Digest Fragment Coverage Analysis
DNA sequence analysis depends on the accurate assembly of fragment reads for the determination of a consensus sequence. This report examines the possibility of analyzing multiple,...
Eric C. Rouchka, David J. States
BMCBI
2005
115views more  BMCBI 2005»
13 years 10 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
BMCBI
2007
233views more  BMCBI 2007»
13 years 10 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong
BMCBI
2007
120views more  BMCBI 2007»
13 years 10 months ago
Phylo-mLogo: an interactive and hierarchical multiple-logo visualization tool for alignment of many sequences
Background: When aligning several hundreds or thousands of sequences, such as epidemic virus sequences or homologous/orthologous sequences of some big gene families, to reconstruc...
Arthur Chun-Chieh Shih, D. T. Lee, Chin-Lin Peng, ...