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BMCBI
2008
136views more  BMCBI 2008»
13 years 10 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash
BMCBI
2008
103views more  BMCBI 2008»
13 years 10 months ago
Discovering multi-level structures in bio-molecular data through the Bernstein inequality
Background: The unsupervised discovery of structures (i.e. clusterings) underlying data is a central issue in several branches of bioinformatics. Methods based on the concept of s...
Alberto Bertoni, Giorgio Valentini
BMCBI
2008
100views more  BMCBI 2008»
13 years 10 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
BMCBI
2006
118views more  BMCBI 2006»
13 years 10 months ago
A graphical model approach to automated classification of protein subcellular location patterns in multi-cell images
Background: Knowledge of the subcellular location of a protein is critical to understanding how that protein works in a cell. This location is frequently determined by the interpr...
Shann-Ching Chen, Robert F. Murphy
BMCBI
2006
104views more  BMCBI 2006»
13 years 10 months ago
Semi-supervised discovery of differential genes
Background: Various statistical scores have been proposed for evaluating the significance of genes that may exhibit differential expression between two or more controlled conditio...
Shigeyuki Oba, Shin Ishii