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RECOMB
2005
Springer
14 years 8 months ago
A Practical Approach to Significance Assessment in Alignment with Gaps
Abstract. Current numerical methods for assessing the statistical significance of local alignments with gaps are time consuming. Analytical solutions thus far have been limited to ...
Nicholas Chia, Ralf Bundschuh
RECOMB
2004
Springer
14 years 8 months ago
A class of edit kernels for SVMs to predict translation initiation sites in eukaryotic mRNAs
The prediction of translation initiation sites (TISs) in eukaryotic mRNAs has been a challenging problem in computational molecular biology. In this paper, we present a new algori...
Haifeng Li, Tao Jiang
NIPS
2008
13 years 10 months ago
Optimization on a Budget: A Reinforcement Learning Approach
Many popular optimization algorithms, like the Levenberg-Marquardt algorithm (LMA), use heuristic-based "controllers" that modulate the behavior of the optimizer during ...
Paul Ruvolo, Ian R. Fasel, Javier R. Movellan
IPPS
2006
IEEE
14 years 2 months ago
Parallel multiple sequence alignment with local phylogeny search by simulated annealing
The problem of multiple sequence alignment is one of the most important problems in computational biology. In this paper we present a new method that simultaneously performs multi...
Jaroslaw Zola, Denis Trystram, Andrei Tchernykh, C...
AI
2003
Springer
14 years 1 months ago
An Improved Ant Colony Optimisation Algorithm for the 2D HP Protein Folding Problem
The prediction of a protein’s structure from its amino-acid sequence is one of the most important problems in computational biology. In the current focus on a widely studied abst...
Alena Shmygelska, Holger H. Hoos