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SPIRE
2005
Springer
14 years 4 months ago
Normalized Similarity of RNA Sequences
We introduce a normalized version of the LCS metric as a new local similarity measure for comparing two RNAs. An O(n2 m lg m) time algorithm is presented for computing the maximum ...
Rolf Backofen, Danny Hermelin, Gad M. Landau, Oren...
CPM
2006
Springer
112views Combinatorics» more  CPM 2006»
14 years 2 months ago
Local Alignment of RNA Sequences with Arbitrary Scoring Schemes
Abstract. Local similarity is an important tool in comparative analysis of biological sequences, and is therefore well studied. In particular, the Smith-Waterman technique and its ...
Rolf Backofen, Danny Hermelin, Gad M. Landau, Oren...
BMCBI
2007
135views more  BMCBI 2007»
13 years 11 months ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
BMCBI
2010
95views more  BMCBI 2010»
13 years 11 months ago
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
Background: In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two de...
Emidio Capriotti, Marc A. Martí-Renom
BMCBI
2010
154views more  BMCBI 2010»
13 years 11 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...