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BIOINFORMATICS
2010
138views more  BIOINFORMATICS 2010»
13 years 9 months ago
Robust unmixing of tumor states in array comparative genomic hybridization data
Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness, and eventually metastasis. It i...
David Tolliver, Charalampos E. Tsourakakis, Ayshwa...
CIBCB
2009
IEEE
13 years 10 months ago
rnaDesign: Local search for RNA secondary structure design
Abstract-- The RNA secondary structure design (SSD) problem is a recently emerging research topic motivated by applications such as customized drug design and the self-assembly of ...
Denny C. Dai, Herbert H. Tsang, Kay C. Wiese
DATAMINE
2006
83views more  DATAMINE 2006»
13 years 9 months ago
Structural Hidden Markov Models Using a Relation of Equivalence: Application to Automotive Designs
Standard hidden Markov models (HMM's) have been studied extensively in the last two decades. It is well known that these models assume state conditional independence of the ob...
Djamel Bouchaffra, Jun Tan
BMCBI
2010
150views more  BMCBI 2010»
13 years 9 months ago
Evolutionary rates at codon sites may be used to align sequences and infer protein domain function
Background: Sequence alignments form part of many investigations in molecular biology, including the determination of phylogenetic relationships, the prediction of protein structu...
Pierre M. Durand, Scott Hazelhurst, Theresa L. Coe...
ICML
2010
IEEE
13 years 10 months ago
Structured Output Learning with Indirect Supervision
We present a novel approach for structure prediction that addresses the difficulty of obtaining labeled structures for training. We observe that structured output problems often h...
Ming-Wei Chang, Vivek Srikumar, Dan Goldwasser, Da...