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ALMOB
2008
92views more  ALMOB 2008»
13 years 9 months ago
Reconstructing phylogenies from noisy quartets in polynomial time with a high success probability
Background: In recent years, quartet-based phylogeny reconstruction methods have received considerable attentions in the computational biology community. Traditionally, the accura...
Gang Wu, Ming-Yang Kao, Guohui Lin, Jia-Huai You
BMCBI
2010
117views more  BMCBI 2010»
13 years 9 months ago
Properties and identification of antibiotic drug targets
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E. coli to id...
Tala Bakheet, Andrew J. Doig
BMCBI
2010
138views more  BMCBI 2010»
13 years 9 months ago
A model-independent approach to infer hierarchical codon substitution dynamics
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
Olof Görnerup, Martin Nilsson Jacobi
BMCBI
2010
105views more  BMCBI 2010»
13 years 9 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
BMCBI
2007
115views more  BMCBI 2007»
13 years 9 months ago
Comparing sequences without using alignments: application to HIV/SIV subtyping
Background: In general, the construction of trees is based on sequence alignments. This procedure, however, leads to loss of informationwhen parts of sequence alignments (for inst...
Gilles Didier, Laurent Debomy, Maude Pupin, Ming Z...