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» On Generating Random Network Structures: Connected Graphs
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101
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BMCBI
2007
115views more  BMCBI 2007»
15 years 2 months ago
How accurate and statistically robust are catalytic site predictions based on closeness centrality?
Background: We examine the accuracy of enzyme catalytic residue predictions from a network representation of protein structure. In this model, amino acid α-carbons specify vertic...
Eric Chea, Dennis R. Livesay
133
Voted
JCB
2002
131views more  JCB 2002»
15 years 2 months ago
Modeling and Simulation of Genetic Regulatory Systems: A Literature Review
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The reg...
Hidde de Jong
109
Voted
ICANN
2005
Springer
15 years 8 months ago
Associative Learning in Hierarchical Self Organizing Learning Arrays
In this paper we introduce feedback based associative learning in self-organized learning arrays (SOLAR). SOLAR structures are hierarchically organized and have the ability to clas...
Janusz A. Starzyk, Zhen Zhu, Yue Li
143
Voted
BMCBI
2010
189views more  BMCBI 2010»
15 years 2 months ago
High quality protein sequence alignment by combining structural profile prediction and profile alignment using SABERTOOTH
Background: Protein alignments are an essential tool for many bioinformatics analyses. While sequence alignments are accurate for proteins of high sequence similarity, they become...
Florian Teichert, Jonas Minning, Ugo Bastolla, Mar...
124
Voted
BMCBI
2010
227views more  BMCBI 2010»
15 years 2 months ago
Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage
Background: HIV-1 targets human cells expressing both the CD4 receptor, which binds the viral envelope glycoprotein gp120, as well as either the CCR5 (R5) or CXCR4 (X4) co-recepto...
Majid Masso, Iosif I. Vaisman