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BMCBI
2005
115views more  BMCBI 2005»
13 years 9 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
BMCBI
2007
166views more  BMCBI 2007»
13 years 9 months ago
Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics
Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of pepti...
Xinning Jiang, Xiaogang Jiang, Guanghui Han, Mingl...
BMCBI
2006
195views more  BMCBI 2006»
13 years 9 months ago
Hubs of knowledge: using the functional link structure in Biozon to mine for biologically significant entities
Background: Existing biological databases support a variety of queries such as keyword or definition search. However, they do not provide any measure of relevance for the instance...
Paul Shafer, Timothy Isganitis, Golan Yona
IJCAI
2003
13 years 10 months ago
Comparing Best-First Search and Dynamic Programming for Optimal Multiple Sequence Alignment
Sequence alignment is an important problem in computational biology. We compare two different approaches to the problem of optimally aligning two or more character strings: bounde...
Heath Hohwald, Ignacio Thayer, Richard E. Korf
SIGMOD
1998
ACM
143views Database» more  SIGMOD 1998»
14 years 1 months ago
Optimal Multi-Step k-Nearest Neighbor Search
For an increasing number of modern database applications, efficient support of similarity search becomes an important task. Along with the complexity of the objects such as images...
Thomas Seidl, Hans-Peter Kriegel