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» On Timed Models of Gene Networks
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JAMIA
2011
94views more  JAMIA 2011»
12 years 10 months ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...
IJFCS
2008
102views more  IJFCS 2008»
13 years 8 months ago
Gene Assembly Models and Boolean Circuits
We propose two different ways to simulate Boolean circuits in the framework of ciliate computations, based on the intramolecular and on the intermolecular gene assembly models wit...
Tseren-Onolt Ishdorj, Ion Petre
ALIFE
2000
13 years 7 months ago
On Meme-Gene Coevolution
In this paper we examine the effects of the emergence of a new replicator, memes, on the evolution of a pre-existing replicator, genes. Using a version of the NKCS model we examin...
Larry Bull, Owen Holland, Susan Blackmore
JCP
2006
157views more  JCP 2006»
13 years 7 months ago
CF-GeNe: Fuzzy Framework for Robust Gene Regulatory Network Inference
Most Gene Regulatory Network (GRN) studies ignore the impact of the noisy nature of gene expression data despite its significant influence upon inferred results. This paper present...
Muhammad Shoaib B. Sehgal, Iqbal Gondal, Laurence ...
BMCBI
2010
178views more  BMCBI 2010»
13 years 8 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...