The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observ...
Richard J. Boys, Darren J. Wilkinson, Thomas B. L....
The effective reverse engineering of biochemical networks is one of the great challenges of systems biology. The contribution of this paper is two-fold: 1) We introduce a new meth...
Background: Gene expression measurements during the development of the fly Drosophila melanogaster are routinely used to find functional modules of temporally co-expressed genes. ...
Ivan G. Costa, Roland Krause, Lennart Opitz, Alexa...
There is a need to develop methods to automatically incorporate prior knowledge to support the prediction and validation of novel functional associations. One such important sourc...
Francisco Azuaje, Haiying Wang, Huiru Zheng, Olivi...
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...