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» On predicting secondary structure transition
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BMCBI
2004
208views more  BMCBI 2004»
13 years 7 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
NIPS
1998
13 years 9 months ago
An Entropic Estimator for Structure Discovery
We introduce a novel framework for simultaneous structure and parameter learning in hidden-variable conditional probability models, based on an entropic prior and a solution for i...
Matthew Brand
GECCO
2005
Springer
124views Optimization» more  GECCO 2005»
14 years 1 months ago
Evolving petri nets to represent metabolic pathways
Given concentrations of metabolites over a sequence of time steps, the metabolic pathway prediction problem seeks a set of reactions and rate constants for them that could yield t...
Jeremiah Nummela, Bryant A. Julstrom
RECOMB
2003
Springer
14 years 7 months ago
A multi-expert system for the automatic detection of protein domains from sequence information
We describe a novel method for detecting the domain structure of a protein from sequence information alone. The method is based on analyzing multiple sequence alignments that are ...
Niranjan Nagarajan, Golan Yona
BMCBI
2006
202views more  BMCBI 2006»
13 years 7 months ago
DWARF - a data warehouse system for analyzing protein families
Background: The emerging field of integrative bioinformatics provides the tools to organize and systematically analyze vast amounts of highly diverse biological data and thus allo...
Markus Fischer, Quan K. Thai, Melanie Grieb, J&uum...