DWARF - a data warehouse system for analyzing protein families

Background: The emerging field of integrative bioinformatics provides the tools to organize and systematically analyze vast amounts of highly diverse biological data and thus allows to gain a novel understanding of complex biological systems. The data warehouse DWARF applies integrative bioinformatics approaches to the analysis of large protein families. Description: The data warehouse system DWARF integrates data on sequence, structure, and functional annotation for protein fold families. The underlying relational data model consists of three major sections representing entities related to the protein (biochemical function, source organism, classification to homologous families and superfamilies), the protein sequence (position-specific annotation, mutant information), and the protein structure (secondary structure information, superimposed tertiary structure). Tools for extracting, transforming and loading data from public available resources (ExPDB, GenBank, DSSP) are provided to p...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Markus Fischer, Quan K. Thai, Melanie Grieb, Jürgen Pleiss
• Keywords: BMCBI 2006, Integrative Bioinformatics, Protein, Protein Families