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BMCBI
2011
15 years 20 days ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman
VLDB
2004
ACM
104views Database» more  VLDB 2004»
16 years 6 months ago
Retrieval effectiveness of an ontology-based model for information selection
Technology in the field of digital media generates huge amounts of nontextual information, audio, video, and images, along with more familiar textual information. The potential for...
Latifur Khan, Dennis McLeod, Eduard H. Hovy
RIAO
1997
15 years 7 months ago
The Do-I-Care Agent: Effective Social Discovery and Filtering on the Web
The Web is a vast, dynamic source of information and resources. Because of its size and diversity, it is increasingly likely that if the information one seeks is not already there...
Mark S. Ackerman, Brian Starr, Michael J. Pazzani
BIOINFORMATICS
2005
140views more  BIOINFORMATICS 2005»
15 years 6 months ago
Profile-based direct kernels for remote homology detection and fold recognition
Motivation: Remote homology detection between protein sequences is a central problem in computational biology. Supervised learning algorithms based on support vector machines are ...
Huzefa Rangwala, George Karypis
SIGCSE
2010
ACM
189views Education» more  SIGCSE 2010»
16 years 1 months ago
Principles of asking effective questions during student problem solving
Using effective teaching practices is a high priority for educators. One important pedagogical skill for computer science instructors is asking effective questions. This paper pre...
Kristy Elizabeth Boyer, William Lahti, Robert Phil...