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» On the Noise Model of Support Vector Machines Regression
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BMCBI
2010
190views more  BMCBI 2010»
13 years 7 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
BMCBI
2007
107views more  BMCBI 2007»
13 years 7 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
BMCBI
2007
140views more  BMCBI 2007»
13 years 7 months ago
Accurate prediction of protein secondary structure and solvent accessibility by consensus combiners of sequence and structure in
Background: Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio...
Gianluca Pollastri, Alberto J. M. Martin, Catherin...
IMSCCS
2007
IEEE
14 years 1 months ago
Asymmetric Bagging and Feature Selection for Activities Prediction of Drug Molecules
Background: Activities of drug molecules can be predicted by QSAR (quantitative structure activity relationship) models, which overcomes the disadvantages of high cost and long cy...
Guo-Zheng Li, Hao-Hua Meng, Mary Qu Yang, Jack Y. ...
KDD
2008
ACM
178views Data Mining» more  KDD 2008»
14 years 7 months ago
Training structural svms with kernels using sampled cuts
Discriminative training for structured outputs has found increasing applications in areas such as natural language processing, bioinformatics, information retrieval, and computer ...
Chun-Nam John Yu, Thorsten Joachims