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BMCBI
2006
140views more  BMCBI 2006»
15 years 4 months ago
MACSIMS : multiple alignment of complete sequences information management system
Background: In the post-genomic era, systems-level studies are being performed that seek to explain complex biological systems by integrating diverse resources from fields such as...
Julie D. Thompson, Arnaud Muller, Andrew M. Waterh...
BMCBI
2006
154views more  BMCBI 2006»
15 years 4 months ago
Analysis with respect to instrumental variables for the exploration of microarray data structures
Background: Evaluating the importance of the different sources of variations is essential in microarray data experiments. Complex experimental designs generally include various fa...
Florent Baty, Michaël Facompré, Jan Wi...
BMCBI
2006
153views more  BMCBI 2006»
15 years 4 months ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...
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BMCBI
2006
104views more  BMCBI 2006»
15 years 4 months ago
MANET: tracing evolution of protein architecture in metabolic networks
Background: Cellular metabolism can be characterized by networks of enzymatic reactions and transport processes capable of supporting cellular life. Our aim is to find evolutionar...
Hee Shin Kim, Jay E. Mittenthal, Gustavo Caetano-A...
BMCBI
2006
133views more  BMCBI 2006»
15 years 4 months ago
An integrated approach to the prediction of domain-domain interactions
Background: The development of high-throughput technologies has produced several large scale protein interaction data sets for multiple species, and significant efforts have been ...
Hyunju Lee, Minghua Deng, Fengzhu Sun, Ting Chen
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