MANET: tracing evolution of protein architecture in metabolic networks

Background: Cellular metabolism can be characterized by networks of enzymatic reactions and transport processes capable of supporting cellular life. Our aim is to find evolutionary patterns and processes embedded in the architecture and function of modern metabolism, using information derived from structural genomics. Description: The Molecular Ancestry Network (MANET) project traces evolution of protein architecture in biomolecular networks. We describe metabolic MANET, a database that links information in the Structural Classification of Proteins (SCOP), the Kyoto Encyclopedia of Genes and Genomes (KEGG), and phylogenetic reconstructions depicting the evolution of protein fold architecture. Metabolic MANET literally 'paints' the ancestries of enzymes derived from rooted phylogenomic trees directly onto over one hundred metabolic subnetworks, enabling the study of evolutionary patterns at global and local levels. An initial analysis of painted subnetworks reveals widespread...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Hee Shin Kim, Jay E. Mittenthal, Gustavo Caetano-Anollés
• Keywords: BMCBI 2006, Cellular Metabolism, Enzymatic Reactions, Metabolic Manet