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» On the rigidity of molecular graphs
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JCB
2006
125views more  JCB 2006»
13 years 7 months ago
Hypothesis Generation in Signaling Networks
Biological signaling networks comprise the chemical processes by which cells detect and respond to changes in their environment. Such networks have been implicated in the regulati...
Derek A. Ruths, Luay Nakhleh, M. Sriram Iyengar, S...
ECML
2005
Springer
14 years 1 months ago
Nonrigid Embeddings for Dimensionality Reduction
Spectral methods for embedding graphs and immersing data manifolds in low-dimensional speaces are notoriously unstable due to insufficient and/or numberically ill-conditioned con...
Matthew Brand
BMCBI
2007
146views more  BMCBI 2007»
13 years 7 months ago
Spatial location and its relevance for terminological inferences in bio-ontologies
Background: An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggr...
Stefan Schulz, Kornél G. Markó, Udo ...
BMCBI
2010
142views more  BMCBI 2010»
13 years 7 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
BMCBI
2010
83views more  BMCBI 2010»
13 years 7 months ago
Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins
Background: Phylogenies capture the evolutionary ancestry linking extant species. Correlations and similarities among a set of species are mediated by and need to be understood in...
William P. Kelly, Michael P. H. Stumpf