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BMCBI
2007
80views more  BMCBI 2007»
13 years 7 months ago
AT excursion: a new approach to predict replication origins in viral genomes by locating AT-rich regions
Background: Replication origins are considered important sites for understanding the molecular mechanisms involved in DNA replication. Many computational methods have been develop...
David S. H. Chew, Ming-Ying Leung, Kwok Pui Choi
BMCBI
2004
128views more  BMCBI 2004»
13 years 7 months ago
Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in struc
Background: We establish that the occurrence of protein folds among genomes can be accurately described with a Weibull function. Systems which exhibit Weibull character can be int...
Artem Cherkasov, Shannan J. Ho Sui, Robert C. Brun...
BMCBI
2006
108views more  BMCBI 2006»
13 years 7 months ago
Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress
Background: In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses t...
Huiquan Wang, Craig J. Benham
BMCBI
2004
144views more  BMCBI 2004»
13 years 7 months ago
GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes
Background: The function of a novel gene product is typically predicted by transitive assignment of annotation from similar sequences. We describe a novel method, GOtcha, for pred...
David M. A. Martin, Matthew Berriman, Geoffrey J. ...
BMCBI
2006
74views more  BMCBI 2006»
13 years 7 months ago
An unsupervised classification scheme for improving predictions of prokaryotic TIS
Background: Although it is not difficult for state-of-the-art gene finders to identify coding regions in prokaryotic genomes, exact prediction of the corresponding translation ini...
Maike Tech, Peter Meinicke