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» Optimal detection of sequence similarity by local alignment
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BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Comparative classification of species and the study of pathway evolution based on the alignment of metabolic pathways
Background: Pathways provide topical descriptions of cellular circuitry. Comparing analogous pathways reveals intricate insights into individual functional differences among speci...
Adi Mano, Tamir Tuller, Oded Béjà, R...
BMCBI
2008
95views more  BMCBI 2008»
13 years 7 months ago
Universal seeds for cDNA-to-genome comparison
Background: To meet the needs of gene annotation for newly sequenced organisms, optimized spaced seeds can be implemented into cross-species sequence alignment programs to accurat...
Leming Zhou, Jonathan Stanton, Liliana Florea
JCB
2007
108views more  JCB 2007»
13 years 7 months ago
A Dynamic Programming Approach for Finding Common Patterns in RNAs
We developed a dynamic programming approach of computing common sequence structure patterns among two RNAs given their primary sequences and their secondary structures. Common pat...
Sven Siebert, Rolf Backofen
RECOMB
2006
Springer
14 years 8 months ago
Domain Architecture in Homolog Identification
Homology identification is the first step for many genomic studies. Current methods, based on sequence comparison, can result in a substantial number of mis-assignments due to the ...
Nan Song, R. D. Sedgewick, Dannie Durand
ALMOB
2006
89views more  ALMOB 2006»
13 years 7 months ago
On the maximal cliques in c-max-tolerance graphs and their application in clustering molecular sequences
Given a set S of n locally aligned sequences, it is a needed prerequisite to partition it into groups of very similar sequences to facilitate subsequent computations, such as the ...
Katharina Anna Lehmann, Michael Kaufmann, Stephan ...