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» Overestimation for Multiple Sequence Alignment
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NAR
2006
119views more  NAR 2006»
13 years 7 months ago
HHsenser: exhaustive transitive profile search using HMM-HMM comparison
HHsenser is the first server to offer exhaustive intermediate profile searches, which it combines with pairwise comparison of hidden Markov models. Starting from a single protein ...
Johannes Söding, Michael Remmert, Andreas Bie...
BMCBI
2004
77views more  BMCBI 2004»
13 years 7 months ago
A structural study for the optimisation of functional motifs encoded in protein sequences
Background: A large number of PROSITE patterns select false positives and/or miss known true positives. It is possible that
Allegra Via, Manuela Helmer-Citterich
RECOMB
2004
Springer
14 years 8 months ago
Multiple organism gene finding by collapsed gibbs sampling
The Gibbs sampling method has been widely used for sequence analysis after it was successfully applied to the problem of identifying regulatory motif sequences upstream of genes. ...
Sourav Chatterji, Lior Pachter
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala
RECOMB
2003
Springer
14 years 8 months ago
Accurate detection of very sparse sequence motifs
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Andreas Heger, Michael Lappe, Liisa Holm