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» Overestimation for Multiple Sequence Alignment
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BMCBI
2006
166views more  BMCBI 2006»
13 years 7 months ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
BMCBI
2005
190views more  BMCBI 2005»
13 years 7 months ago
Species-specific analysis of protein sequence motifs using mutual information
Background: Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles de...
Jan Hummel, Nima Keshvari, Wolfram Weckwerth, Joac...
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
13 years 6 months ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang
BMCBI
2006
129views more  BMCBI 2006»
13 years 7 months ago
BIPAD: A web server for modeling bipartite sequence elements
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...
Chengpeng Bi, Peter K. Rogan
BMCBI
2008
101views more  BMCBI 2008»
13 years 7 months ago
Scipio: Using protein sequences to determine the precise exon/intron structures of genes and their orthologs in closely related
Background: For many types of analyses, data about gene structure and locations of non-coding regions of genes are required. Although a vast amount of genomic sequence data is ava...
Oliver Keller, Florian Odronitz, Mario Stanke, Mar...