Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Background: Two problems complicate the study of selection in viral genomes: Firstly, the presence of genes in overlapping reading frames implies that selection in one reading fra...
Saskia de Groot, Thomas Mailund, Gerton Lunter, Jo...
Background: Metalloproteins are proteins capable of binding one or more metal ions, which may be required for their biological function, for regulation of their activities or for ...
Andrea Passerini, Claudia Andreini, Sauro Menchett...
Background: Population structure is an important cause leading to inconsistent results in population-based association studies (PBAS) of human diseases. Various statistical method...
Background: Probability based statistical learning methods such as mutual information and Bayesian networks have emerged as a major category of tools for reverse engineering mecha...