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BMCBI
2008
145views more  BMCBI 2008»
13 years 7 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
89views more  BMCBI 2008»
13 years 7 months ago
Increasing the efficiency of bacterial transcription simulations: When to exclude the genome without loss of accuracy
Background: Simulating the major molecular events inside an Escherichia coli cell can lead to a very large number of reactions that compose its overall behaviour. Not only should ...
Marco A. J. Iafolla, Guang Qiang Dong, David R. Mc...
BMCBI
2008
118views more  BMCBI 2008»
13 years 7 months ago
Kismeth: Analyzer of plant methylation states through bisulfite sequencing
Background: There is great interest in probing the temporal and spatial patterns of cytosine methylation states in genomes of a variety of organisms. It is hoped that this will sh...
Eyal Gruntman, Yijun Qi, R. Keith Slotkin, Ted Roe...
BMCBI
2007
176views more  BMCBI 2007»
13 years 7 months ago
The Firegoose: two-way integration of diverse data from different bioinformatics web resources with desktop applications
Background: Information resources on the World Wide Web play an indispensable role in modern biology. But integrating data from multiple sources is often encumbered by the need to...
J. Christopher Bare, Paul T. Shannon, Amy K. Schmi...
BMCBI
2007
164views more  BMCBI 2007»
13 years 7 months ago
The Personal Sequence Database: a suite of tools to create and maintain web-accessible sequence databases
Background: Large molecular sequence databases are fundamental resources for modern bioscientists. Whether for project-specific purposes or sharing data with colleagues, it is oft...
Scott A. Givan, Christopher M. Sullivan, James C. ...