Proteases play a fundamental role in the control of intra- and extracellular processes by binding and cleaving specific amino acid sequences. Identifying these targets is extremel...
— A fuzzy neural network (FNN) and multiple linear regression (MLR) were used to predict biological activities of 26 newly designed HIV-1 protease potential inhibitory compounds....
Background: Activated Protein C (ProC) is an anticoagulant plasma serine protease which also plays an important role in controlling inflammation and cell proliferation. Several mu...
Pasqualina D'Ursi, Francesca Marino, Andrea Caprer...
Background: The binding of regulatory proteins to their specific DNA targets determines the accurate expression of the neighboring genes. The in silico prediction of new binding s...
Background: The construction of complex spatial simulation models such as those used in network epidemiology, is a daunting task due to the large amount of data involved in their ...