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BMCBI
2010
110views more  BMCBI 2010»
13 years 9 months ago
GenHtr: a tool for comparative assessment of genetic heterogeneity in microbial genomes generated by massive short-read sequenci
Background: Microevolution is the study of short-term changes of alleles within a population and their effects on the phenotype of organisms. The result of the below-species-level...
GongXin Yu
BMCBI
2008
94views more  BMCBI 2008»
13 years 9 months ago
Conserved co-expression for candidate disease gene prioritization
Background: Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between gen...
Martin Oti, Jeroen van Reeuwijk, Martijn A. Huynen...
BMCBI
2008
145views more  BMCBI 2008»
13 years 9 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2010
153views more  BMCBI 2010»
13 years 9 months ago
Challenges in microarray class discovery: a comprehensive examination of normalization, gene selection and clustering
Background: Cluster analysis, and in particular hierarchical clustering, is widely used to extract information from gene expression data. The aim is to discover new classes, or su...
Eva Freyhult, Mattias Landfors, Jenny Önskog,...
BMCBI
2007
102views more  BMCBI 2007»
13 years 9 months ago
A comprehensive system for evaluation of remote sequence similarity detection
Background: Accurate and sensitive performance evaluation is crucial for both effective development of better structure prediction methods based on sequence similarity, and for th...
Yuan Qi, Ruslan Sadreyev, Yong Wang, Bong-Hyun Kim...
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