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BMCBI
2005
126views more  BMCBI 2005»
13 years 10 months ago
GANN: Genetic algorithm neural networks for the detection of conserved combinations of features in DNA
Background: The multitude of motif detection algorithms developed to date have largely focused on the detection of patterns in primary sequence. Since sequence-dependent DNA struc...
Robert G. Beiko, Robert L. Charlebois
BMCBI
2005
95views more  BMCBI 2005»
13 years 10 months ago
Oligomeric protein structure networks: insights into protein-protein interactions
Background: Protein-protein association is essential for a variety of cellular processes and hence a large number of investigations are being carried out to understand the princip...
K. V. Brinda, Saraswathi Vishveshwara
BMCBI
2005
103views more  BMCBI 2005»
13 years 10 months ago
SeqDoC: rapid SNP and mutation detection by direct comparison of DNA sequence chromatograms
Background: This paper describes SeqDoC, a simple, web-based tool to carry out direct comparison of ABI sequence chromatograms. This allows the rapid identification of single nucl...
Mark L. Crowe
BMCBI
2005
103views more  BMCBI 2005»
13 years 10 months ago
Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery
Background: Molecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor tissues (data points). Given such...
Leslie Grate
BMCBI
2005
102views more  BMCBI 2005»
13 years 10 months ago
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computatio
Background: A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription...
Emmitt R. Jolly, Chen-Shan Chin, Ira Herskowitz, H...
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