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BMCBI
2006
198views more  BMCBI 2006»
13 years 8 months ago
Gene selection and classification of microarray data using random forest
Background: Selection of relevant genes for sample classification is a common task in most gene expression studies, where researchers try to identify the smallest possible set of ...
Ramón Díaz-Uriarte, Sara Alvarez de ...
BIOINFORMATICS
2006
129views more  BIOINFORMATICS 2006»
13 years 8 months ago
Predicting methylation status of CpG islands in the human brain
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
Fang Fang, Shicai Fan, Xuegong Zhang, Michael Q. Z...
RECOMB
2010
Springer
13 years 10 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
BIOINFORMATICS
2005
134views more  BIOINFORMATICS 2005»
13 years 8 months ago
Outcome signature genes in breast cancer: is there a unique set?
Motivation: direct bearing whose expres Sorlie et al., 2 gene sets is a diseases (Lossos et al., 2004; Miklos and Maleszka, 2004), and the variables that could account questions i...
Liat Ein-Dor, Itai Kela, Gad Getz, David Givol, Ey...
BMCBI
2011
13 years 11 days ago
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in Bre
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
Hiroko K. Solvang, Ole Christian Lingjærde, ...