Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growt...
Ping Ye, Brian D. Peyser, Forrest A. Spencer, Joel...
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Background: Biological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of int...
Svetlana Pacifico, Guozhen Liu, Stephen Guest, Jod...
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
When using machine learning for in silico modeling, the goal is normally to obtain highly accurate predictive models. Often, however, models should also bring insights into intere...