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BMCBI
2008
94views more  BMCBI 2008»
13 years 8 months ago
Conserved co-expression for candidate disease gene prioritization
Background: Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between gen...
Martin Oti, Jeroen van Reeuwijk, Martijn A. Huynen...
BMCBI
2010
84views more  BMCBI 2010»
13 years 8 months ago
Testing the additional predictive value of high-dimensional molecular data
Background: While high-dimensional molecular data such as microarray gene expression data have been used for disease outcome prediction or diagnosis purposes for about ten years i...
Anne-Laure Boulesteix, Torsten Hothorn
BMCBI
2007
168views more  BMCBI 2007»
13 years 8 months ago
GOSim - an R-package for computation of information theoretic GO similarities between terms and gene products
Background: With the increased availability of high throughput data, such as DNA microarray data, researchers are capable of producing large amounts of biological data. During the...
Holger Fröhlich, Nora Speer, Annemarie Poustk...
BMCBI
2010
190views more  BMCBI 2010»
13 years 8 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
NIPS
2003
13 years 9 months ago
Fast Feature Selection from Microarray Expression Data via Multiplicative Large Margin Algorithms
New feature selection algorithms for linear threshold functions are described which combine backward elimination with an adaptive regularization method. This makes them particular...
Claudio Gentile