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BMCBI
2007
94views more  BMCBI 2007»
13 years 8 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...
BIBE
2005
IEEE
121views Bioinformatics» more  BIBE 2005»
14 years 2 months ago
RNA Pseudoknot Prediction Using Term Rewriting
RNA plays a critical role in mediating every step of cellular information transfer from genes to functional proteins. Pseudoknots are widely occurring structural motifs found in a...
Xuezheng Fu, Hao Wang, William L. Harrison, Robert...
BMCBI
2010
191views more  BMCBI 2010»
13 years 3 months ago
Molecular dynamics simulation studies and in vitro site directed mutagenesis of avian beta-defensin Apl_AvBD2
Background: Defensins comprise a group of antimicrobial peptides, widely recognized as important elements of the innate immune system in both animals and plants. Cationicity, rath...
Soja Saghar Soman, Krishnankutty Chandrika Sivakum...
BMCBI
2004
111views more  BMCBI 2004»
13 years 8 months ago
The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases
Background: The Hotdog fold was initially identified in the structure of Escherichia coli FabA and subsequently in 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. strain CB...
Shane C. Dillon, Alex Bateman
TREC
2003
13 years 10 months ago
Knowledge-Based Access to the Bio-Medical Literature, Ontologically-Grounded Experiments for the TREC 2003 Genomics Track
The Tarragon Consulting team participated in the primary task of the TREC 2003 Genomics Track. We used a combination of knowledge-engineering and corpus analysis to construct sema...
Richard Tong, John Quackenbush, Mark Snuffin