A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
Background: The accurate determination of orthology and inparalogy relationships is essential for comparative sequence analysis, functional gene annotation and evolutionary studie...
Benjamin Linard, Julie D. Thompson, Olivier Poch, ...
Background: Alternative splicing (AS) is a process which generates several distinct mRNA isoforms from the same gene by splicing different portions out of the precursor transcript...
Johannes Eichner, Georg Zeller, Sascha Laubinger, ...
Machine-learning algorithms are employed in a wide variety of applications to extract useful information from data sets, and many are known to suffer from superlinear increases in ...
Karthik Nagarajan, Brian Holland, Alan D. George, ...
The prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysi...