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» Predicting protein function from domain content
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BMCBI
2005
114views more  BMCBI 2005»
13 years 10 months ago
Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and stru
Background: Protein kinases are a well defined family of proteins, characterized by the presence of a common kinase catalytic domain and playing a significant role in many importa...
Luciano Milanesi, Mauro Petrillo, Leandra Sepe, An...
BMCBI
2010
159views more  BMCBI 2010»
13 years 11 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao
NAR
2008
100views more  NAR 2008»
13 years 10 months ago
DAhunter: a web-based server that identifies homologous proteins by comparing domain architecture
We present DAhunter, a web-based server that identifies homologous proteins by comparing domain architectures, the organization of protein domains. A major obstacle in comparison ...
Byungwook Lee, Doheon Lee
ENGL
2008
121views more  ENGL 2008»
13 years 11 months ago
Prediction of Protein-Protein Interactions Using Pairwise Alignment and Inter-Domain Linker Region
One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains...
Nazar Zaki
BMCBI
2005
75views more  BMCBI 2005»
13 years 10 months ago
Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
Hartmut Scheel, Kay Hofmann