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» Predicting the beta-helix fold from protein sequence data
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NAR
1998
73views more  NAR 1998»
13 years 7 months ago
Identification and characterization of the RAD51 gene from the ciliate Tetrahymena thermophila
The RAD51 gene is a eukaryotic homolog of recA, a critical component in homologous recombination and DNA repair pathways in Escherichia coli. We have cloned the RAD51 homolog from...
Colin Campbell, Daniel P. Romero
ICML
2008
IEEE
14 years 8 months ago
Sequence kernels for predicting protein essentiality
The problem of identifying the minimal gene set required to sustain life is of crucial importance in understanding cellular mechanisms and designing therapeutic drugs. This work d...
Cyril Allauzen, Mehryar Mohri, Ameet Talwalkar
BMCBI
2008
75views more  BMCBI 2008»
13 years 7 months ago
A three-state prediction of single point mutations on protein stability changes
Background: A basic question of protein structural studies is to which extent mutations affect the stability. This question may be addressed starting from sequence and/or from str...
Emidio Capriotti, Piero Fariselli, Ivan Rossi, Rit...
BMCBI
2008
121views more  BMCBI 2008»
13 years 7 months ago
iRefIndex: A consolidated protein interaction database with provenance
Background: Interaction data for a given protein may be spread across multiple databases. We set out to create a unifying index that would facilitate searching for these data and ...
Sabry Razick, George Magklaras, Ian M. Donaldson
RECOMB
2006
Springer
14 years 8 months ago
Improving Prediction of Zinc Binding Sites by Modeling the Linkage Between Residues Close in Sequence
Abstract. We describe and empirically evaluate machine learning methods for the prediction of zinc binding sites from protein sequences. We start by observing that a data set consi...
Sauro Menchetti, Andrea Passerini, Paolo Frasconi,...