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BMCBI
2010
174views more  BMCBI 2010»
13 years 8 months ago
The effect of prior assumptions over the weights in BayesPI with application to study protein-DNA interactions from ChIP-based h
Background: To further understand the implementation of hyperparameters re-estimation technique in Bayesian hierarchical model, we added two more prior assumptions over the weight...
Junbai Wang
JCB
2007
144views more  JCB 2007»
13 years 8 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
BMCBI
2007
216views more  BMCBI 2007»
13 years 8 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
EMNLP
2006
13 years 10 months ago
Automatic Construction of Predicate-argument Structure Patterns for Biomedical Information Extraction
This paper presents a method of automatically constructing information extraction patterns on predicate-argument structures (PASs) obtained by full parsing from a smaller training...
Akane Yakushiji, Yusuke Miyao, Tomoko Ohta, Yuka T...
BMCBI
2011
13 years 9 days ago
Determinants of Antigenicity and Specificity in immune response for Protein Sequences
Background: Target specific antibodies are pivotal for the design of vaccines, immunodiagnostic tests, studies on proteomics for cancer biomarker discovery, identification of prot...
Yulong Wang, Wenjun Wu, Nicolas N. Negre, Kevin P....