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BMCBI
2008
133views more  BMCBI 2008»
13 years 7 months ago
ElliPro: a new structure-based tool for the prediction of antibody epitopes
Background: Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics. A correlation between a...
Julia V. Ponomarenko, Huynh-Hoa Bui, Wei Li, Nicho...
BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
BMCBI
2007
147views more  BMCBI 2007»
13 years 7 months ago
Improved residue contact prediction using support vector machines and a large feature set
Background: Predicting protein residue-residue contacts is an important 2D prediction task. It is useful for ab initio structure prediction and understanding protein folding. In s...
Jianlin Cheng, Pierre Baldi
BMCBI
2010
141views more  BMCBI 2010»
13 years 7 months ago
Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles
Background: Enzymes belonging to acyl:CoA synthetase (ACS) superfamily activate wide variety of substrates and play major role in increasing the structural and functional diversit...
Pankaj Khurana, Rajesh S. Gokhale, Debasisa Mohant...
BMCBI
2004
125views more  BMCBI 2004»
13 years 7 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...