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BMCBI
2007
113views more  BMCBI 2007»
13 years 7 months ago
Statistical power of phylo-HMM for evolutionarily conserved element detection
Background: An important goal of comparative genomics is the identification of functional elements through conservation analysis. Phylo-HMM was recently introduced to detect conse...
Xiaodan Fan, Jun Zhu, Eric E. Schadt, Jun S. Liu
BMCBI
2007
145views more  BMCBI 2007»
13 years 7 months ago
Improved benchmarks for computational motif discovery
Background: An important step in annotation of sequenced genomes is the identification of transcription factor binding sites. More than a hundred different computational methods h...
Geir Kjetil Sandve, Osman Abul, Vegard Walseng, Fi...
BMCBI
2007
159views more  BMCBI 2007»
13 years 7 months ago
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
Background: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results: We ...
Israel Mark Martínez-Pérez, Gong Zha...
BMCBI
2007
177views more  BMCBI 2007»
13 years 7 months ago
The BioPrompt-box: an ontology-based clustering tool for searching in biological databases
Background: High-throughput molecular biology provides new data at an incredible rate, so that the increase in the size of biological databanks is enormous and very rapid. This sc...
Claudio Corsi, Paolo Ferragina, Roberto Marangoni
IJAR
2006
125views more  IJAR 2006»
13 years 7 months ago
Computing best-possible bounds for the distribution of a sum of several variables is NP-hard
In many real-life situations, we know the probability distribution of two random variables x1 and x2, but we have no information about the correlation between x1 and x2; what are ...
Vladik Kreinovich, Scott Ferson