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» Problems on RNA Secondary Structure Prediction and Design
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BMCBI
2010
105views more  BMCBI 2010»
13 years 8 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
JCB
2007
144views more  JCB 2007»
13 years 8 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
AAAI
2007
13 years 11 months ago
Predictive Exploration for Autonomous Science
Often remote investigations use autonomous agents to observe an environment on behalf of absent scientists. Predictive exploration improves these systems’ efficiency with onboa...
David R. Thompson
WOSS
2004
ACM
14 years 2 months ago
Combining statistical monitoring and predictable recovery for self-management
Complex distributed Internet services form the basis not only of e-commerce but increasingly of mission-critical networkbased applications. What is new is that the workload and in...
Armando Fox, Emre Kiciman, David A. Patterson
SIAMSC
2008
106views more  SIAMSC 2008»
13 years 8 months ago
Finite Volume Simulation of the Geostrophic Adjustment in a Rotating Shallow-Water System
The goal of this article is to simulate rotating flows of shallow layers of fluid by means of finite volume numerical schemes. More precisely, we focus on the simulation of the geo...
Manuel J. Castro, Juan Antonio López, Carlo...