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BMCBI
2006
111views more  BMCBI 2006»
13 years 7 months ago
High throughput profile-profile based fold recognition for the entire human proteome
Background: In order to maintain the most comprehensive structural annotation databases we must carry out regular updates for each proteome using the latest profile-profile fold r...
Liam J. McGuffin, Richard T. Smith, Kevin Bryson, ...
CSB
2003
IEEE
176views Bioinformatics» more  CSB 2003»
14 years 26 days ago
3D Structural Homology Detection via Unassigned Residual Dipolar Couplings
Recognition of a protein’s fold provides valuable information about its function. While many sequence-based homology prediction methods exist, an important challenge remains: tw...
Christopher James Langmead, Bruce Randall Donald
ILP
1998
Springer
13 years 11 months ago
Application of Inductive Logic Programming to Discover Rules Governing the Three-Dimensional Topology of Protein Structure
Abstract. Inductive Logic Programming (ILP) has been applied to discover rules governing the three-dimensional topology of protein structure. The data-set unifies two sources of in...
Marcel Turcotte, Stephen Muggleton, Michael J. E. ...
BMCBI
2004
208views more  BMCBI 2004»
13 years 7 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
BMCBI
2007
113views more  BMCBI 2007»
13 years 7 months ago
Learning biophysically-motivated parameters for alpha helix prediction
Background: Our goal is to develop a state-of-the-art protein secondary structure predictor, with an intuitive and biophysically-motivated energy model. We treat structure predict...
Blaise Gassend, Charles W. O'Donnell, William Thie...