Background: The Smith-Waterman algorithm for local sequence alignment is more sensitive than heuristic methods for database searching, but also more time-consuming. The fastest ap...
The Protein Information Resource (PIR) produces the largest, most comprehensive, annotated protein sequence database in the public domain, the PIRInternational Protein Sequence Da...
Winona C. Barker, John S. Garavelli, Hongzhan Huan...
Background: Biologists are often interested in performing a simple database search to identify proteins or genes that contain a well-defined sequence pattern. Many databases do no...
The use of controlled structured vocabularies for annotation purposes, such as the Gene Ontology (GO) is currently one of the strategies to cope with the increasingly cumbersome t...
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...