Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Searching and mining large graphs today is critical to a variety of application domains, ranging from personalized recommendation in social networks, to searches for functional ass...
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
Background: Sequence motifs representing transcription factor binding sites (TFBS) are commonly encoded as position frequency matrices (PFM) or degenerate consensus sequences (CS)...
There has been an explosion of hyperlinked data in many domains, e.g., the biological Web. Expressive query languages and effective ranking techniques are required to convert this...