Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
Background: Hierarchical clustering is a widely applied tool in the analysis of microarray gene expression data. The assessment of cluster stability is a major challenge in cluste...
Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of pepti...
Astronomy increasingly faces the issue of massive datasets. For instance, the Sloan Digital Sky Survey (SDSS) has so far generated tens of millions of images of distant galaxies, ...
Brigham Anderson, Andrew W. Moore, Andrew Connolly...
The success of "infinite-inventory" retailers such as Amazon.com and Netflix has been ascribed to a "long tail" phenomenon. To wit, while the majority of their...
Andrei Z. Broder, Bo Pang, Evgeniy Gabrilovich, Sh...