Abstract. There have been many widely used genome rearrangement models, such as reversals, HannenhalliPevzner, and double-cut and join. Though each one can be precisely defined, t...
In this paper, we investigate the computational efficiency of gene rearrangement operations found in ciliates, a type of unicellular organisms. We show how the so-called guided re...
In the past years, many combinatorial arguments have been made to support the theory that mammalian genome rearrangement scenarios rely heavily on breakpoint reuse. Different model...
Abstract. The intramolecular model for gene assembly in ciliates considers three operations, ld, hi, and dlad that can assemble any gene pattern through folding and recombination: ...
Tero Harju, Ion Petre, Vladimir Rogojin, Grzegorz ...
We study the problem of transforming a multichromosomal genome into another using Double-Cut-and-Join (DCJ) operations. We introduce the notion of DCJ scenario that does not break ...