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BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
ISLPED
2004
ACM
139views Hardware» more  ISLPED 2004»
14 years 26 days ago
Eliminating voltage emergencies via microarchitectural voltage control feedback and dynamic optimization
Microprocessor designers use techniques such as clock gating to reduce power dissipation. An unfortunate side-effect of these techniques is the processor current fluctuations th...
Kim M. Hazelwood, David Brooks
KBSE
2003
IEEE
14 years 22 days ago
Specification and Synthesis of Hybrid Automata for Physics-Based Animation
Physics-based animation programs can often be modeled in terms of hybrid automata. A hybrid automaton includes both discrete and continuous dynamical variables. The discrete varia...
Thomas Ellman
PLDI
2005
ACM
14 years 1 months ago
TraceBack: first fault diagnosis by reconstruction of distributed control flow
Faults that occur in production systems are the most important faults to fix, but most production systems lack the debugging facilities present in development environments. TraceB...
Andrew Ayers, Richard Schooler, Chris Metcalf, Ana...
AIPS
2009
13 years 8 months ago
Flexible Execution of Plans with Choice
Dynamic plan execution strategies allow an autonomous agent to respond to uncertainties while improving robustness and reducing the need for an overly conservative plan. Executive...
Patrick R. Conrad, Julie A. Shah, Brian C. William...