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» Reconstructing the pre-doubling genome
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CIBCB
2007
IEEE
14 years 4 months ago
An Experimental Evaluation of Inversion-and Transposition-Based Genomic Distances through Simulations
— Rearrangements of genes and other syntenic blocks have become a topic of intensive study by phylogenists, comparative genomicists, and computational biologists: they are a feat...
Moulik Kothari, Bernard M. E. Moret
BMCBI
2010
135views more  BMCBI 2010»
13 years 10 months ago
GIGA: a simple, efficient algorithm for gene tree inference in the genomic age
Background: Phylogenetic relationships between genes are not only of theoretical interest: they enable us to learn about human genes through the experimental work on their relativ...
Paul D. Thomas
NAR
2006
177views more  NAR 2006»
13 years 9 months ago
PUMA2 - grid-based high-throughput analysis of genomes and metabolic pathways
The PUMA2 system (available at http://compbio.mcs. 10 anl.gov/puma2) is an interactive, integrated bioinformatics environment for high-throughput genetic sequence analysis and met...
Natalia Maltsev, Elizabeth M. Glass, Dinanath Sula...
BMCBI
2005
102views more  BMCBI 2005»
13 years 9 months ago
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computatio
Background: A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription...
Emmitt R. Jolly, Chen-Shan Chin, Ira Herskowitz, H...
RECOMB
2010
Springer
13 years 8 months ago
Consistency of Sequence-Based Gene Clusters
In comparative genomics, various combinatorial models can be used to specify gene clusters — groups of genes that are co-located in a set of genomes. Several approaches have been...
Roland Wittler, Jens Stoye