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» SUPFAM: A database of sequence superfamilies of protein doma...
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ISMB
1998
13 years 9 months ago
Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...
Imran Shah, Lawrence Hunter
BMCBI
2008
141views more  BMCBI 2008»
13 years 7 months ago
The development of PIPA: an integrated and automated pipeline for genome-wide protein function annotation
Background: Automated protein function prediction methods are needed to keep pace with high-throughput sequencing. With the existence of many programs and databases for inferring ...
Chenggang Yu, Nela Zavaljevski, Valmik Desai, Seth...
NAR
2010
94views more  NAR 2010»
13 years 2 months ago
Saccharomyces Genome Database provides mutant phenotype data
The Saccharomyces Genome Database (SGD; http:// www.yeastgenome.org) is a scientific database for the molecular biology and genetics of the yeast Saccharomyces cerevisiae, which i...
Stacia R. Engel, Rama Balakrishnan, Gail Binkley, ...
BMCBI
2008
86views more  BMCBI 2008»
13 years 7 months ago
Subfamily specific conservation profiles for proteins based on n-gram patterns
Background: A new algorithm has been developed for generating conservation profiles that reflect the evolutionary history of the subfamily associated with a query sequence. It is ...
John K. Vries, Xiong Liu
BMCBI
2010
159views more  BMCBI 2010»
13 years 7 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao