The mechanism of gene regulation has been studied intensely for decades. It is important to identify synergistic transcriptional motifs. Its search space is so large that an effici...
Modularity is thought to improve the evolvability of biological systems [18, 22]. Recent studies in the field of evolutionary computation show that the use of modularity improves...
Abstract. Computational inference of transcriptional regulatory networks remains a challenging problem, in part due to the lack of strong network models. In this paper we present e...
Background: Modeling cancer-related regulatory modules from gene expression profiling of cancer tissues is expected to contribute to our understanding of cancer biology as well as...
Background: The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false po...
Matthew S. Hestand, Michiel van Galen, Michel P. V...