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» Searching on the Secondary Structure of Protein Sequences
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RECOMB
2006
Springer
14 years 7 months ago
Detecting the Dependent Evolution of Biosequences
Abstract. A probabilistic graphical model is developed in order to detect the dependent evolution between different sites in biological sequences. Given a multiple sequence alignme...
Jeremy Darot, Chen-Hsiang Yeang, David Haussler
GECCO
2006
Springer
176views Optimization» more  GECCO 2006»
13 years 11 months ago
A genetic algorithm with backtracking for protein structure prediction
In this paper, we propose a simple genetic algorithm for finding the optimal conformation of a protein using the three-dimensional square HP model. A backtracking procedure is use...
Clayton Matthew Johnson, Anitha Katikireddy
BMCBI
2005
162views more  BMCBI 2005»
13 years 7 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
CSB
2005
IEEE
143views Bioinformatics» more  CSB 2005»
14 years 1 months ago
Analysis of four different sets of predictive features for metalloproteins
Metals bound to the protein are important for functional or structural roles. Despite their importance there is a distinct lack of research for identification of metalloproteins f...
Huseyin Seker, Parvez I. Haris
BMCBI
2006
85views more  BMCBI 2006»
13 years 7 months ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen